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Studying the effect of chronic toxicity of monosodium glutamate on interleukin-10 and interleukin-17 in albino Wistar rats

Research Abstract

Objective

This study aimed to assess the effect of chronic administration of Monosodium Glutamate (MSG) on blood cells, thymus, spleen, and inflammatory indicators through interleukin (IL)-17 and interleukin (IL)-10 gene expression levels in blood and in thymic and spleen tissues in male Wistar rats.

Methods

Rats were treated with MSG orally once daily for 90 days at two different doses with and without probiotic supplementation (Bacillus Subtilis and Bacillus Pumilus). Blood samples were collected for CBC, IL-10, and IL-17 gene expression in blood. The spleen and thymus were taken for histological and immunohistochemical studies.

Results

WBC results showed no significant difference among groups. A statistically significant higher mean IL-10 was observed among the low dose with probiotic (group 4) compared to other groups. There was a significantly higher mean of IL17 among low dose without probiotic (group 2). The mean level of IL-17 was high among group 4. Sections from thymus and spleen of MSG groups showed histological derangement. Immunohistochemical staining in tissues supported the observed gene expression levels in blood. Groups with higher cytokine gene expression generally showed stronger tissue staining, confirming consistency between transcription and protein levels and this strengthens interpretation of MSG-induced immune alterations.

Conclusion

High-dose MSG was associated with a decreased level of IL-10 with various degrees of tissue inflammation. Adding probiotics to low-dose MSG resulted in increased levels of IL-10 in blood. The low serum level of IL-17 in the high-dose MSG groups was associated with high degrees of inflammation with little improvement with probiotic.

Research Authors
Fatma Sayed Abd-Elsamea, Asmaa HM Soliman, Asmaa Abdo Abdelrahman, Omar Ali Mohamed Farghaly, Mostafa Sabry, Asmaa A Rayan
Research Journal
Immunopharmacology and Immunotoxicology
Research Member
Research Pages
148-163
Research Publisher
Taylor & Francis
Research Rank
International
Research Vol
48 (1)
Research Year
2026

The Dean of the College inspects the readiness of educational facilities and units within the framework of preparations for the new academic year 2026-2027

Within the framework of the keenness of the college administration to provide a safe and distinguished educational environment, and to complete the intensive preparations to receive the new academic year,  Prof. Dr.  Enas Ahmed Abdel Hafez, Dean of the College, conducted an  extensive inspection tour to follow up on the readiness of educational facilities and units, and to check on their readiness to receive students and the regularity of the educational process from the first day.

The tour included laboratories, terraces, buildings and educational facilities, an animal house, and the diagnostic radiology unit, where His  Excellency was keen  to inspect the equipment and facilities, check on the maintenance work, ensure the availability of safety and security requirements, in addition to following up on the regularity and proper functioning of work in various sectors.

This came in the presence of Prof. Dr. Mahmoud Mustafa,  Director of the Veterinary Teaching Hospital, where during the tour, the readiness of the facilities and related equipment was assessed, and the necessary preparations were followed up to ensure the regularity of work and provide a safe and suitable environment for students and workers.

Prof.   Dr. Enas Ahmed Abdel Hafez, Dean of the College, also directed the need to complete all equipment and maintenance works within the specified times, and to deal immediately with any observations that may affect the efficiency of operation or the safety of students and workers, stressing that creating a safe and integrated educational environment is a key priority to ensure a successful start to the new academic year.

This tour comes within the framework of the educational preparations for the new academic year, and the keenness of the college administration to ensure the readiness of various facilities, units and equipment that serve the educational and training process, in a way that contributes to providing an integrated academic environment that supports the quality of education and training.

At the end of the tour, the college's administration confirmed that it will continue to exert all efforts to complete educational preparations, improve the level of performance, and provide a safe and stimulating educational environment, in line with the aspirations of its students and support the college's march towards more excellence, quality and leadership.

 

Congratulations from the Dean of the College to Professor Ashraf Mohamed Abdel-Malek, Vice Dean for Graduate Studies and Research, on his selection to the Scientific Council of the Egyptian Board.

Congratulations from the Dean of the College to Professor Ashraf Mohamed Abdel-Malek, Vice Dean for Graduate Studies and Research, on his selection to the Scientific Council of the Egyptian Board.


 

Congratulations from the Faculty of Veterinary Medicine, headed by Professor Dr. Enas Ahmed Abdel Hafez, Dean of the Faculty, and Professor Dr. Ahmed Abdel Mawla.

تتقدم اسرة كلية الطب البيطري وعلى رأسها 

 ا.د/ايناس احمد عبد الحافظ  

عميد كلية الطب البيطري  

 والسادة الوكلاء والسادة أعضاء هيئة التدريس  ومعاونيهم والجهاز الإدارى وطلاب الكلية  

بأسمى التهاني القلبية إلى 

معالي ا. د/احمد عبد المولي نائب رئيس الجامعة لشئون التعليم والطلاب 

بمناسبة صدور قرار الأستاذ الدكتور  وزير التعليم العالي والبحث العلمي بتوليه القيام بأعمال رئيس جامعة أسيوط

 متمنين لسيادته دوام التوفيق والسداد،في خدمة الجامعة ومنتسبيها ومزيداً من التقدم والنجاح. 

 كما تتقدم اسرة الكلية 

بخالص الشكر والتقدير الى 

 معالي الأستاذ الدكتور أحمد المنشاوي 

رئيس جامعة أسيوط

 تقديراً لجهوده المخلصة وعطائه المستمر خلال فترة توليه رئاسة الجامعة،

 وما قدمه من دعم ورؤية طموحة أسهمت في تحقيق العديد  من الانجازات التي عززت مكانة جامعة أسيوط

 سائلين الله لسيادته دوام التوفيق والسداد، 

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